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    Current Research Maintenance of a correct number of chromosomes is necessary for organismal development and survival. Animal cells maintain a correct diploid chromosome number by equally segregating their DNA chromosomes into two daughter cells at each division cycle.

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    When chromosome segregation does not occur correctly, daughter cells with abnormal chromosome numbers are produced.

    Abnormal chromosome numbers are a distinctive feature of cancer cells and such chromosome number changes are believed to contribute to cancer progression.

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    Therefore, understanding the mechanisms leading to inaccurate chromosome segregation is critical for understanding the process of carcinogenesis and will be Danila Options starting point for the development of diagnosis, prevention, and treatment protocols. Our laboratory uses a combination of live-cell imaging, quantitative microscopy, and protein inhibition to identify the cellular and molecular mechanisms underlying normal and abnormal cell division behaviors.

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    To enhance the breadth and scope of our work, we often collaborate with engineers and mathematical modelers. Virginia Tech, Dept.

    • Michelle Danila - Toole Design
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